J. Tourniaire et al., PREVALENCE OF ANTIGLIADIN ANTIBODIES IN D IABETIC (TYPE-1 AND TYPE-2)AND NONDIABETIC ADULT-POPULATIONS, La Presse medicale, 24(31), 1995, pp. 1425-1427
Objectives: The level of circulating antigliadin antibodies is an esse
ntial element in diabetic patients with signs of coeliac disease. Into
lerance to gluten can disrupt glucose regulation leading to greater ri
sk of hypoglycaemia. Search for antigliadin antibodies could be a rout
ine test in diabetics. Methods: Plasma gliadin antibodies were measure
d by immunoenzymatic assay in adult subjects: 80 type 1 diabetics, 80
type 2 diabetics, 80 non diabetics without auto-immune disease. Result
s: IgA antibodies were present in 6 type 1 diabetics (7.5%), 8 type 2
diabetics (10%) and 6 non-diabetics (7.5%). Anti-reticulin and anti-en
domysium antibodies were measured in type I diabetics with antigliadin
e antibodies. They were present only in one patient (Tunisian) who suf
fered from a coeliac disease. Conclusion: In France, the prevalence of
coeliac disease is very low. Antigliadin antibodies measurement is ju
stified only in patients with clinical and/or biological symptoms of c
oeliac disease.