L. Foucan et al., BLOOD-PRESSURE AND URINARY ALBUMIN EXCRET ION IN ADULT PATIENTS WITH SICKLE-CELL DISEASE, La Presse medicale, 24(31), 1995, pp. 1428-1432
Objective: The increase of urinary albumin excretion could be associat
ed with morbidity in patients with sickle cell disease. The objective
of this study was to evaluate the relation between blood pressure and
urinary albumin excretion, and to estimate the prevalence of hypertens
ion according to the level of urinary albumin excretion. Methods: A cr
oss-sectional study was carried in 77 patients,vith sickle cell diseas
e (48 patients with haemoglobin SS, 29 with haemoglobin SC) et 30 cont
rols with haemoglobin AA. The patients with sickle cell disease were d
ivided into 3 groups according to urinary albumin excretion: less than
30 mg daily (group I: normoalbuminuria); from 30 to 300 mg daily (gro
up II: microalbuminuria); above 300 mg daily (group III: macroalbuminu
ria). All AA selected controls had normoalbuminuria (group IV). Result
s: In normoalbuminuric patients, the average of blood pressure was sig
nificantly lower in patients with sickle cell disease than in controls
(respectively 115.0 +/- 8.1 vs 132.1 +/- 15.1, p = 4.10(-6) for systo
lic pressure and 67.2 +/- 8.0 vs 78.8 +/- 9.8 mmHg, p = 10(-4) for dia
stolic pressure). There was a positive relation between urinary albumi
n excretion, even moderate (values less than or equal to 300 mg daily)
and blood pressure in SS patients (r = 0.40, p < 0.02 for systolic an
d r = 0.54, p < 0.01 for diastolic pressure) and in SC patients (r = 0
.74, p < 0.001 and r = 0.58, p < 0.01). The prevalence of hypertension
was 0% in group I, 25% in group II and 66% in group III. Conclusion:
The positive association between blood pressure and urinary albumin ex
cretion suggests that the latter should be taken into account in sickl
e cell disease's follow up.