Trichorzianines A and B obtained from Trichoderma harzianum were teste
d on the mycelial growth of Sclerotium rolfsii. Bioassays evidenced th
at the trichorzianines had different inhibitory activity. These metabo
lites produced a change in the morphogenetic pattern of mycelia. Bioas
says also showed that trichorzianines A inhibited the own mycelia of T
. harzianum, which could be considered as an absence of immunity. Effe
cts of trichorzianines on plasma membrane are discussed.