AN IMMUNODOMINANT ANTIGEN OF BRUGIA-MALAYI IS AN ASPARAGINYL-TRANSFER-RNA SYNTHETASE

Authors
KRON M MARQUARD K HARTLEIN M PRICE S LEBERMAN R
Citation
M. Kron et al., AN IMMUNODOMINANT ANTIGEN OF BRUGIA-MALAYI IS AN ASPARAGINYL-TRANSFER-RNA SYNTHETASE, FEBS letters, 374(1), 1995, pp. 122-124
Citations number
17
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
374
Issue
1
Year of publication
1995
Pages
122 - 124
Database
ISI
SICI code
0014-5793(1995)374:1<122:AIAOBI>2.0.ZU;2-J
Abstract
Lymphatic filariasis is caused by infection with the filarial nematode s Brugia malayi, Brugia timori, Wuchereria bancrofti and Onchocerca vo lvulus which collectively infect about 200 million persons throughout the world. Protein sequence homology analysis of a major nematode anti gen suggested that it was a class II aminoacyl-tRNA synthetase. The ov erproduction, purification and verification that the major B. malayi a ntigen is an asparaginyl-tRNA synthetase is described.