DEVELOPMENTAL EXPRESSION PATTERN SCREEN FOR GENES PREDICTED IN THE C-ELEGANS GENOME SEQUENCING PROJECT

Maximum use should be made of information generated in the genome sequ encing projects. Toward this end, we have initiated a genome sequence- based, expression pattern screen of genes predicted from the Caenorhab ditis elegans genome sequence data. We examined beta-galactosidase exp ression patterns in C. elegans lines transformed with lacZ reporter ge ne fusions constructed using predicted C. elegans gene promoter region s. Of the predicted genes in the cosmids analysed so far, 67% are amen able to the approach and 54% of examined genes yielded a developmental expression pattern. Expression pattern information is being made gene rally available using computer databases.