A RECOMBINANT CANARYPOX VIRUS PROTECTS RABBITS AGAINST A LETHAL RABBIT HEMORRHAGIC-DISEASE VIRUS (RHDV) CHALLENGE

Authors
FISCHER L LEGROS FX MASON PW PAOLETTI E
Citation
L. Fischer et al., A RECOMBINANT CANARYPOX VIRUS PROTECTS RABBITS AGAINST A LETHAL RABBIT HEMORRHAGIC-DISEASE VIRUS (RHDV) CHALLENGE, Vaccine, 15(1), 1997, pp. 90-96
Citations number
32
Categorie Soggetti
Immunology
Journal title
Vaccine → ACNP
ISSN journal
0264410X
Volume
15
Issue
1
Year of publication
1997
Pages
90 - 96
Database
ISI
SICI code
0264-410X(1997)15:1<90:ARCVPR>2.0.ZU;2-K
Abstract
An ALVAC (canarypox)-based recombinant virus ALVAC-RHDV (vCP309) expre ssing a native rabbit hemorrhagic disease virus (RHDV) capsid protein was derived and assessed for its protective efficacy in rabbits Protec tion against a lethal RHDV challenge was demonstrated in rabbits inocu lated twice with either high (10(7) p.f.u.) or low (10(5) p.f.u.) dose s of vCP309. However, animals in the high nose group developed signifi cantly higher antibody response. These results have implications that are relevant to the development of a safe rabbit hemorrhagic disease ( RHD) vaccine and further illustrate the utility of the ALVAC vector sy stem to elicit protective immune responses in nonavian species. Copyri ght (C) 1997 Elsevier Science Ltd.