TETRODECAMYCIN AND DIHYDROTETRODECAMYCIN, NEW ANTIMICROBIAL ANTIBIOTICS AGAINST PASTEURELLA-PISCICIDA PRODUCED BY STREPTOMYCES-NASHVILLENSIS MJ885-MF8 .1. TAXONOMY, FERMENTATION, ISOLATION, CHARACTERIZATION AND BIOLOGICAL-ACTIVITIES

Authors
TSUCHIDA T IINUMA H NISHIDA C KINOSHITA N SAWA T HAMADA M TAKEUCHI T
Citation
T. Tsuchida et al., TETRODECAMYCIN AND DIHYDROTETRODECAMYCIN, NEW ANTIMICROBIAL ANTIBIOTICS AGAINST PASTEURELLA-PISCICIDA PRODUCED BY STREPTOMYCES-NASHVILLENSIS MJ885-MF8 .1. TAXONOMY, FERMENTATION, ISOLATION, CHARACTERIZATION AND BIOLOGICAL-ACTIVITIES, Journal of antibiotics, 48(10), 1995, pp. 1104-1109
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
48
Issue
10
Year of publication
1995
Pages
1104 - 1109
Database
ISI
SICI code
0021-8820(1995)48:10<1104:TADNAA>2.0.ZU;2-H
Abstract
The novel antimicrobial antibiotic against Pasteurella piscicida, tetr odecamycin (1) and weakly active dihydrotetrodecamycin (2) were isolat ed from the fermentation broth of Streptomyces nashvillensis MJ885-mF8 . They were purified by adsorption on Diaion HP-20, silica gel column chromatography and crystallization. The MICs of 1 were 6.25 similar to 12.5 mu g/liter and 1.56 similar to 6.25 mu g/ml against Gram-positiv e bacteria including methicillin-resistant Staphylococcus aureus (MRSA ) and 12 strains of P. piscicida, respectively.