CD2-, CD56(, CD3)NCAM+ MALIGNANT-LYMPHOMA WITH TCR-BETA GENE REARRANGEMENT - A CASE-REPORT/

A case of CD56/NCAM + malignant lymphoma is reported. Only a rare mali gnant lymphoma cell showed azurophilic granules in the cytoplasm of Gi esma-stained preparations, while electron microscopic examination reve aled occasional cytoplasmic granules with paracrystalline inclusions. The most common phenotype seen in NK lymphomas, CD2+, CD3-, CD56+, CD1 6-, CD57-, was present in the case. Cases with this phenotype have bee n interpreted to represent either true NK lymphoma or T-cell lymphoma with NK expression. Genotyping, where performed, has shown TCR germlin e configuration. Our case showed TCR beta rearrangement indicating tha t the above phenotype can be associated with a peripheral T-cell lymph oma. (C) 1995 Wiley-Liss, Inc.