SUPRAMOLECULAR ASSEMBLY OF SUBSTITUTED HYDROXY-BISPHOSPHONATES WITH CUPRIC ION - INFLUENCE OF THE CHAIN FUNCTIONALIZATION

As part of a general study of hydroxy-bisphosphonic acids (HEBP), R-C( OH)(PO3H)(2), three Cu (II) complexes with R=CH3; R=-(CH2)(3)-NH2 and R=-(CH2)(5)-NH2, were prepared and analysed by X-Ray diffraction metho ds. The substitution of the methyl group in HEBP (($) under bar 3) by an aminopropyl (($) under bar 1) or by an aminopentyl (($) under bar 2 ) chain led to a drastic modification of the ionic self-assembly in th e crystal and completely different polyhedral complexation networks ar ound the Cu (II). A polymeric chain formation is observed in (($) unde r bar 3), whereas (($) under bar 1) and (($) under bar 2) display disc rete tetrameric and dimeric arrangements. The results are discussed on the basis of the environment of the phosphorus atoms and the molecula r geometry around the central carbon atom of the hydroxy-bisphosphonic moiety. These results are further compared to their ability for ionic transport and/or extraction.