Impact forces have been speculated to be associated with the developme
nt of musculoskeletal injuries. However, several findings indicate tha
t the concepts of ''impact forces'' and the paradigms of their ''cushi
oning'' may not be well understood in relation to the etiology of runn
ing injuries and that complex mechanisms may be responsible for injury
development during running. The purposes of this paper are (a) to rev
iew impact mechanics during locomotion, (b) to review injuries and cha
nges of biological tissue due to impact loading, and (c) to synthesize
the mechanical and biological findings. In addition, directions for f
uture research are discussed. Future research should address the devel
opment of noninvasive techniques to assess changes in the morphology a
nd biochemistry of bone, cartilage, tendon, and ligaments; researchers
should also try to simulate impact loading during activities such as
running, focusing on the interaction of the various loading parameters
that determine the acceptable windows of loading for biological tissu
es.