ASSOCIATION BETWEEN GENETIC-VARIATION OF THE LIPOPROTEIN-LIPASE GENE AND COMBINED HYPERLIPIDEMIA

In view of the effects of lipoprotein lipase (LPL) on plasma lipid lev els, we have analysed the association between LPL polymorphism and lip id levels in the combined hyperlipidemic subjects, The allele frequenc y of the PvuII polymorphic site showed a significant difference betwee n control and combined hyperlipidemic groups (P<0.005). But there was no significant difference in the allele frequency of the HindIII polym orphic site, Each polymorphic site had values of relatively high heter ozygosity and polymorphism information content (PIC). The P1P1 genotyp e of the PvuII site was associated with elevated triglyceride levels i n the combined hyperlipidemic group. Subjects with a heterozygous geno type had intermediate levels of triglyceride. Thus, PvuII polymorphism indicated a gene dosage effect on the triglyceride levels in the comb ined hyperlipidemic group, Compared to the PvuII site, the HindIII sit e showed little association with lipid levels, The effects of LPL poly morphism on lipid profiles varies significantly among racial or ethnic groups, So we have discussed the clinical importance of these RFLPs.