DISSEMINATED MYCOBACTERIUM-MARINUM INFECTION AND BACTEREMIA IN A CHILD WITH SEVERE COMBINED IMMUNODEFICIENCY

We report an unusual case of disseminated dermatitis, osteomyelitis, a nd bacteremia in an immunocompromised host. An infant presented with a pustular skin rash resembling chicken pox, but culture of a skin lesi on yielded Mycobacterium marinum. Upon further evaluation, severe comb ined immunodeficiency was diagnosed. Radiographs of the hands and feet showed evidence of osteomyelitis. M. marinum was isolated from blood and synovial fluid. We recommend a high level of suspicion for this or ganism in immunocompromised hosts who have been exposed to fresh water or salt water, particularly those of aquaria. Drug susceptibility tes ting of serial clinical isolates from our patient revealed development of high-level resistance to isoniazid and rifampin during therapy. We believe that treatment of disseminated M. marinum infections should i nclude combinations of antimycobacterial agents chosen on the basis of results of susceptibility testing done by an experienced laboratory, thereby limiting the emergence of drug resistance.