A 60-HZ MAGNETIC-FIELD INCREASES THE INCIDENCE OF SQUAMOUS-CELL CARCINOMAS IN MICE PREVIOUSLY EXPOSED TO CHEMICAL CARCINOGENS

Authors
MCLEAN J THANSANDOTE A LECUYER D GODDARD M TRYPHONAS L SCAIANO JC JOHNSON F
Citation
J. Mclean et al., A 60-HZ MAGNETIC-FIELD INCREASES THE INCIDENCE OF SQUAMOUS-CELL CARCINOMAS IN MICE PREVIOUSLY EXPOSED TO CHEMICAL CARCINOGENS, Cancer letters, 92(2), 1995, pp. 121-125
Citations number
43
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
92
Issue
2
Year of publication
1995
Pages
121 - 125
Database
ISI
SICI code
0304-3835(1995)92:2<121:A6MITI>2.0.ZU;2-V
Abstract
The exposure of tumor-bearing SENCAR mice to a magnetic field of 2 mT at a frequency of 60 Hz for 52 weeks, was found to increase the rate o f malignant conversion in chemically-induced dorsal skin papillomas. D etailed histopathology revealed the presence of squamous cell papillom as and squamous cell carcinomas in both sham and magnetic field expose d mice at week 52. However, of the nine mice assessed as having squamo us cell carcinomas, eight came from the group exposed to magnetic fiel ds, a difference which is statistically significant at P = 0.03.