LIV.52 PRETREATMENT INHIBITS THE RADIATION-INDUCED LIPID-PEROXIDATIONIN MOUSE-LIVER

The effect of Liv.52 on mice liver mitochondrial lipid peroxidation wa s measured in terms of malanoldehyde (MDA) generation after exposure t o 3.0 Gy of gamma radiation at 1/4, 1/2, 1, 2, 4, 8, 24 and 48 h post- irradiation. The lipid peroxidation level increased significantly from 1/4 h and reached a peak level at 4 h post-irradiation, and gradually declined thereafter in the irradiated control group. Liv.52 treatment before irradiation inhibited the formation of lipid peroxidation sign ificantly at all the post-irradiation sampling time.