PHYSIOLOGICAL-CHARACTERISTICS OF NOVEL AG GRESSOTROPIC NEUROPEPTIDES

Physiological effects of the structural analogs of earlier unknown neu ropeptides. isolated from the bovine brain were studied. It was shown that intraventricularly and intraperitoneally, administered peptides s trongly affected different kinds of aggressive behaviour of rats. In a ddition, the peptides under study influenced various kinds of behaviou r presumably Linked to formation of the aggressive slate of the animal (food and water intake, fear, locomotion). The findings suggest that the peptides modulate dopamine-, serotonin- and glutamatergic neurotra nsmission which underlie neurochemical mechanisms of aggressive activi ty.