FORMATION OF TASTE-AVERSION AND PREFERENC E UNDER CONDITIONS OF PROTEIN-SYNTHESIS INHIBITION IN RATS

The study is devoted to the role of protein synthesis in formation of chemosensory memory in rats. Two experimental models of taste memorizi ng were.-used, i. e., conditioned taste aversion (CTA) caused by assoc iation of succharin intake with being poisoned by lithium chloride, an d increased taste preference (ITP) caused by the influence of primary consumption of succharin solution on its repeated intake. It was found out that CTA was not formed under conditions both of 43% inhibition o f brain protein synthesis by cycloheximide and of 59% its inhibition b y 8-azaguanine. Cycloheximide but not 8-azaguanine prevented formation of ITP. A proposal was made about participation of different spectra of protein and peptide molecules in formation of taste aversion and pr eference. The effect of protein synthesis inhibitors on the process of taste memory retrieval was not found.