NEUROPHYSIOLOGICAL MECHANISMS OF NEUROTRO PIN ACTION ON AVOIDANCE-CONDITIONING AND EXTINCTION IN RABBITS

Effects of neurotropin (NSP), a substance extracted from the inflammat ory dermis of rabbits inoculated with Vaccine virus, on avoidance cond itioning and extinction were studied in rabbits. Intravenous administr ation of NSP produced reorganization of the neuronal activity in CA(1) area of the hippocampus making it more regular. Under the influence o f NSP conditioned heart rate bradicardia became more expressed. NSP le d to longer persistence of avoidance response during extinction. Under the action of NSP time patterns of intersignal neuronal activity, hea rt rate and respiration were similar to those during conditioning tria ls. The results suggest that NSP administration activates intersignal retention process which results in more steady consolidation of avoida nce behaviour.