SOLID-PHASE SYNTHESIS OF BICYCLO[2.2.2]OCTANE DERIVATIVES VIA TANDEM MICHAEL ADDITION-REACTIONS AND SUBSEQUENT REDUCTIVE AMINATION

Authors
LEY SV MYNETT DM KOOT WJ
Citation
Sv. Ley et al., SOLID-PHASE SYNTHESIS OF BICYCLO[2.2.2]OCTANE DERIVATIVES VIA TANDEM MICHAEL ADDITION-REACTIONS AND SUBSEQUENT REDUCTIVE AMINATION, Synlett, (10), 1995, pp. 1017
Citations number
43
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
10
Year of publication
1995
Database
ISI
SICI code
0936-5214(1995):10<1017:SSOBDV>2.0.ZU;2-K
Abstract
Tandem Michael addition reactions of polymer bound acrylates with cycl ohexenones and subsequent reductive amination was achieved, which afte r cleavage from the support under reductive, acidolytic or aminolytic conditions afforded of a wide variety of bicyclo[2.2.2]octanes. The pr ocess may find application in combinatorial library synthesis.