EFFICIENT SYNTHESIS OF CHIRAL PROPARGYL ALCOHOLS BY ENANTIOSELECTIVE TITANIUM-TADDOLATE CATALYZED ADDITION OF DIMETHYLZINC TO 3-TRIMETHYLSILYL-2-PROPYNAL

Authors
OGUNI N SATOH N FUJII H
Citation
N. Oguni et al., EFFICIENT SYNTHESIS OF CHIRAL PROPARGYL ALCOHOLS BY ENANTIOSELECTIVE TITANIUM-TADDOLATE CATALYZED ADDITION OF DIMETHYLZINC TO 3-TRIMETHYLSILYL-2-PROPYNAL, Synlett, (10), 1995, pp. 1043
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
10
Year of publication
1995
Database
ISI
SICI code
0936-5214(1995):10<1043:ESOCPA>2.0.ZU;2-3
Abstract
A practical and efficient synthesis of chiral propargyl alcohols was a chieved by the enantioselective addition of dimethylzinc to 3-trimethy lsilyl (TMS)-2-propynal (5) using titanium-TADDOLate (alpha, alpha, al pha', 2,2-disubstituted-1,3-dioxolane-4,5-dimethanolate) catalysts.