DESTRUCTIVE LYMPHADENOPATHY AND T-LYMPHOCYTE ACTIVATION IN ADULT-ONSET STILLS DISEASE

Recurrent arthritis, fever and lymphadenopathy are symptoms of adult o nset of Still's disease (AOSD). Differential diagnosis requires the ex clusion of infections or malignant lymphomas. We report on a case of A OSD showing destructive lymphadenopathy, immunophenotyping of peripher al blood leucocytes revealed strong activation of T-lymphocytes. Bone marrow biopsy also showed an increase of lymphopoietic cells to 23%. A nalysis of peripheral blood lymphocytes (PBL) after remission showed n o remaining signs of activation. Analysis of lymphocyte activation by flow cytometry correlated with disease activity.