Collagenous colitis is a disease of unknown etiology characterized by
diarrhea that responds poorly to conventional antidiarrheal therapy or
therapy for inflammatory bowel disease. Octreotide is recognized as a
treatment of diarrhea of varying causes, but we could find no previou
s reports of its use in collagenous colitis. We therefore report a sev
ere case of collagenous colitis that responded to regular subcutaneous
octreotide therapy.