EFFECT OF URSODEOXYCHOLIC ACID ON BIOCHEMICAL PARAMETERS, HEPATOCYTE PROLIFERATION AND LIVER HISTOLOGY IN GALACTOSAMINE HEPATITIS IN THE RAT

Authors
RUDI J SCHLENKER T RAEDSCH R WALDHERR R ZORN M STREMMEL W
Citation
J. Rudi et al., EFFECT OF URSODEOXYCHOLIC ACID ON BIOCHEMICAL PARAMETERS, HEPATOCYTE PROLIFERATION AND LIVER HISTOLOGY IN GALACTOSAMINE HEPATITIS IN THE RAT, Research in experimental medicine, 195(5), 1995, pp. 309-315
Citations number
37
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Research in experimental medicine → ACNP
ISSN journal
03009130
Volume
195
Issue
5
Year of publication
1995
Pages
309 - 315
Database
ISI
SICI code
0300-9130(1995)195:5<309:EOUAOB>2.0.ZU;2-B
Abstract
The effect of oral administration of ursodeoxycholic acid (UDCA) on bi ochemical parameters, liver histology and liver cell proliferation was investigated in rats with galactosamine hepatitis. Treatment with UDC A led to a decrease of aminotransferases, but did not show any signifi cant changes in liver histology or liver cell proliferation. The impro vement of liver enzymes without change of histology in this animal mod el of hepatitis following treatment with UDCA is in agreement with res ults obtained from clinical trials with UDCA in patients with chronic viral hepatitis.