COMBINED THERAPY WITH INTERLEUKIN-2 AND INDOMETHACIN IN MICE INOCULATED WITH MH134 HEPATOMA

The antitumor effects of indomethacin and interleukin 2 (IL-2) were st udied in C3H/HeJ mice inoculated with MH134 hepatoma cells. Combined t reatment with indomethacin and IL-2 augmented natural killer (NK) cell s in mice with MH134-induced peritoneal carcinomatosis, and the surviv al of the treated mice was significantly longer than the non-treated m ice. In animals with subcutaneous MH134 tumors, the combined therapy w ith indomethacin and IL-2 significantly suppressed tumor growth and in duced complete regression of the tumor in three out of five mice. Thes e results suggest that indomethacin and IL-2 therapy could be effectiv e on human gastrointestinal cancer cells as well.