EFFECT OF CIGARETTE-SMOKE ON LIPID-PEROXIDATION AND LIVER-FUNCTION TESTS IN RATS

The effect of cigarette smoke on organ weights, lipid peroxidation and plasma biochemical parameters was investigated in male Wistar rats. D aily exposure (for 20 min twice a day) to cigarette smoke for 27 days caused a significant decrease in liver weight and a significant increa se in lung weight. The smoke-exposure group showed increased lipid per oxidation in the liver, but not in the lung. In the smoke-exposure gro up, the GOT, gamma-GTP, total bilirubin and LDH values were significan tly higher than those in the control group, while the plasma glucose v alue was significantly lower. These results suggest that cigarette smo king might induce liver injury by enhancing lipid peroxidation.