Xo. Fu et al., ENZYME-INHIBITORS - NEW AND KNOWN POLYBROMINATED PHENOLS AND DIPHENYLETHERS FROM 4 INDO-PACIFIC DYSIDEA SPONGES, Journal of natural products, 58(9), 1995, pp. 1384-1391
Extracts and pure compounds isolated from four samples of Dysidea sp.
sponges collected from two geographically distinct regions of the Indo
-Pacific (Chuuk Atoll and Fiji) mere assayed against five different en
zyme assays, four of which are relevant to anticancer drug discovery a
nd one of which (15-lipoxygenase) may detect compounds significant in
modulating the development of atherosclerotic plaque. The pure compoun
ds that inhibited various enzymes were polybrominated phenols and poly
brominated phenoxyphenols. Fourteen of these phenols were isolated, si
x of which were new compounds. A variety of the phenols inhibited inos
ine monophosphate dehydrogenase (IMPDH), guanosine monophosphate synth
etase, and 15-lipoxygenase. No activity was observed with protein tyro
sine kinase pp60(v-src) or matrix metalloprotease.