SATURATED HETEROCYCLES .226. COPPER(II) CHLORIDE AS AN EFFICIENT REAGENT FOR THE DEHYDROGENATION OF PYRIDAZINONE DERIVATIVES

Authors
CSENDE F SZABO Z BERNATH G STAJER G
Citation
F. Csende et al., SATURATED HETEROCYCLES .226. COPPER(II) CHLORIDE AS AN EFFICIENT REAGENT FOR THE DEHYDROGENATION OF PYRIDAZINONE DERIVATIVES, Synthesis, (10), 1995, pp. 1240-1242
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
10
Year of publication
1995
Pages
1240 - 1242
Database
ISI
SICI code
0039-7881(1995):10<1240:SH.CCA>2.0.ZU;2-C
Abstract
A new procedure is described for the preparation of pyridazinones from 4,5-dihydropyridazinones under mild conditions with CuCl2 in MeCN via halogenation and spontaneous HCl elimination. For the trans-hexahydro phthalazin-8(1H)-one 1B, the HCl elimination is five times faster tha n for the corresponding cis isomer 1B.