A. Pirozhkov et al., JOINT INFLUENCE OF NATURAL KILLERS (NK) AND HEMATOPOIETIC STROMA ON REJECTION OF PARENT STEM-CELLS, Bone marrow transplantation, 16(5), 1995, pp. 683-693
The growth of hemopoietic stem cells of C57BL/6 mice was explored in s
yngeneic and semi-syngeneic foci of heterotopic hemopoiesis, formed un
der the kidney capsule of (CBA x C57BL/6)F-1 recipients with and witho
ut prior treatment with cyclophosphamide or fractionated irradiation,
which is known to abrogate hybrid resistance and NK cell activity. Our
results show that the suppression of the growth of parent stem cells
in semi-syngeneic F-1-recipients is due to NK cell participation, Howe
ver, no inhibition was found in the growth of identical cells in the f
oci of syngeneic hemopoietic stroma in the same recipients, despite th
e presence of NK cell activity. The experimental model used shows clea
rly that hybrid resistance is the result of the joint involvement of N
K cells and the semi-syngeneic stroma.