Isolated myoclonus has rarely been. reported as a complication of Plas
modium falciparum malaria. We describe the development of chaotic myoc
lonic jerks in an afebrile and conscious patient, the fourth day of tr
eatment with quinine for P. falciparum infection. The myoclonus finall
y resulted in a generalized tonic-clonic seizure and coma, which resol
ved without further antimalarial treatment.