C. Mathis et al., GENETIC-ANALYSIS OF ANXIETY-RELATED BEHAVIORS AND RESPONSES TO BENZODIAZEPINE-RELATED DRUGS IN AXB AND BXA RECOMBINANT INBRED MOUSE STRAINS, Behavior genetics, 25(6), 1995, pp. 557-568
Recombinant inbred (RI) strains derived from the C57BL/6J and A/J mous
e strains were used for behavioral studies designed to estimate the nu
mber and location of chromosomal loci responsible for anxiety-related
behaviors and differential sensitivity to agonists and inverse agonist
s of the gamma-aminobutyric acid(A) (GABA(A))/benzodiazepine receptor
complex. The phenotypes of the parental inbred strains and of 28 Rl st
rains were characterized for the number of transitions in the light =
dark exploratory model, anxiolytic response to diazepam, vertical and
ambulatory activities in an open field, and sensitivity to the convuls
ant properties of methyl-beta-carboline-3-carboxylate (beta-CCM). The
strain distribution patterns and estimates of the minimal number of lo
ci obtained for each trait suggest that multiple chromosomal loci cont
ribute to differences in anxiety-related behavioral phenotypes and the
behavioral responses to diazepam and beta-CCM between C57BL/6J and A/
J mice. The best probabilities of linkage were found between the varia
bles characterizing response to diazepam and loci on chromosomes 1 (Xm
v-41) and 10 (D10Mit2) and between the sensitivity to the convulsant a
ctions of beta-CCM and locus D15Mit5 on chromosome 15.