GENETIC-MAPPING AND EXPRESSION ANALYSIS OF THE MURINE DNA-LIGASE-I GENE

We mapped the murine DNA ligase I gene (Lig1) in the mouse genome by u sing a mapping panel from an interspecific cross. Lig1 mapped to a cen tromeric part of chromosome 7, a region homologous to human chromosome 19q, where the human homologue LIG1 was localized. In addition, Lig1 expression was analyzed during the course of mouse liver-cell regenera tion induced by partial hepatectomy, necrogenic doses of carbon tetrac hloride, or the mitogen 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene. Th e results demonstrate that Lig1 is expressed in the liver during activ e cell proliferation. (C) 1995 Wiley-Liss, Inc.