An induction of metallothionein by spinach extract was studied in mice
. Among determined vegetables. the greatest effect was observed after
injection of spinach extract. Injection of the extract induced metallo
thionein in a dose-dependent manner. Metallothionein was induced not o
nly in the liver but in the kidney by injection of the extract. A fibr
inogen level in the blood increased after injection of the extract. It
indicates that cytokine may be involved in the induction of metalloth
ionein by the spinach extract.