AUTOMATED-ANALYSIS OF NUCLEAR-MAGNETIC-RESONANCE ASSIGNMENTS FOR PROTEINS

Authors
ZIMMERMAN DE MONTELIONE GT
Citation
De. Zimmerman et Gt. Montelione, AUTOMATED-ANALYSIS OF NUCLEAR-MAGNETIC-RESONANCE ASSIGNMENTS FOR PROTEINS, Current opinion in structural biology, 5(5), 1995, pp. 664-673
Citations number
65
Categorie Soggetti
Cell Biology",Biology
Journal title
Current opinion in structural biology → ACNP
ISSN journal
0959440X
Volume
5
Issue
5
Year of publication
1995
Pages
664 - 673
Database
ISI
SICI code
0959-440X(1995)5:5<664:AONAFP>2.0.ZU;2-J
Abstract
Recent developments in protein NMR technology provide spectral data th at are highly amenable to analysis by computer software systems. Autom ated methods of analysis use constraint satisfaction, pseudoenergy min imization, directed search, neural net, simulated annealing, and/or ge netic algorithms to establish sequential links and sequence-specific a ssignments. The most advanced systems provide automated analysis of co mplete backbone and extensive side-chain resonance assignments for pro teins of 50-150 amino acids.