This study examines the levels of fluctuating dental asymmetry in four
samples of school children: those whose mothers were obese and had sm
oked during the pregnancy concerned (n = 111); those whose mothers wer
e obese non-smokers (n = 114); those whose mothers were non-obese smok
ers (n = 104); and those whose mothers were lean non-smokers (n = 111)
, The degree of fluctuating asymmetry was assessed by means of a resca
led asymmetry measure. Obesity was defined as Quetelet's index in exce
ss of 30, and smoking status as at least 20 cigarettes per day during
the pregnancy concerned. When the magnitudes of fluctuating asymmetry
in children of lean smokers were compared to the control group of lean
nonsmokers, no significant univariate differences were found. Childre
n of obese mothers, whether these smoked or not, were found to have si
gnificantly raised levels of asymmetry. An analysis of variance confir
med that the combination of obesity and maternal smoking was a signifi
cant predictor of fluctuating dental asymmetry, The teeth involved ten
ded to be the maxillary first incisor and molars. It is concluded that
maternal obesity has a destabilizing effect on the developing fetus a
nd that this effect appears to be enhanced in obese mothers who smoked
. This effect was absent in lean mothers, irrespective of their smokin
g status. (C) 1997 Wiley-Liss, Inc.