MULTIPLE-SCLEROSIS AND AMYLOID DEPOSITS IN THE WHITE-MATTER OF THE BRAIN

We present the neuropathological findings in a female patient with cli nically definite multiple sclerosis (MS), who at autopsy had multifoca l amyloid deposits in the white matter of the brain without other sign s of amyloidosis. The patient had relapsing/remitting MS between the a ges of 26 and 45, and during her last 14 years she had a secondary chr onic progressive form of MS. Previous reports of amyloid deposits in M S are reviewed and the possible relationship between amyloid deposits and the increased production of immunoglobulin free light chains in MS is discussed.