EFFECT OF SELENIUM ON THE CHANGE IN CADMIUM-INDUCED DISTRIBUTION OF TRACE-ELEMENTS IN PREGNANT RATS

To probe into the antagonistic mechanism of selenium on the toxicity o f cadmium (Cd)-induced embryos and pregnant rats, the effect of supple ment selenium (Se) on change of trace elements distribution and Cd-red istribution in Cd-induced Wistar rats was studied. 18 pregnant rats. o n 0 day of gestation were divided into 3 groups. A group - Cd toxicati on, B Group - Cd toxicaion + Se inhibited, C group - control. The resu lts showed that 1. copper (Cu), zinc (Zn), manganese (Mn), Se and Cd d istributions in group A had significantly changed compared with group C: Cu contents increased in blood, liver and kidney; Zn and Se content s decreased remarkably; Mn decreased in blood, but increased in kidney and did not significantly change in Liver, while Cd contents in blood , liver and kidney were much higher than that of group C, which were 1 217.5, 1305, 773.1 times as many as control group respectively. 2. Ora l administration Se led to Cd redistribution in blood, liver, kidney o f group B; (Cd decreased 78.0%, 50.3%, 53.0% respectively compared wit h group A) and had interference and antagonistic effect on the change in Cd-induced distribution of Cu, Zn, Mn, Se in rats; the content of b lood Cu was significantly higher than that in group A and C (p < 0.01) ; the contents of Cu in liver and kidney were remarkably lower than th at in group A (p < 0.01); Zn, Se contents were increased; blood Mn hig her, while Liver and kidney Mn lower than that ingroup A (p < 0.01). T he results indicated that antagonistic mechanism of Se against toxicit y of Cd-induced embryos and pregnant rats could lead to Cd-redistribut ion and decrease free-Cd concentration in blood, liver and kidney; bes ides, Se also had remarkable antagonistic effect on the change in Cd-i nduced distribution of Cu, Zn, Mn, Se in rats, which enabled the distr ibution of these trace elements to approach normal equilibrium.