HEMATOPOIESIS REPAIR AFTER ALLOMYELOTRANS PLANTATION AND AUTOMYELOTRANSPLANTATION IN PATIENTS WITH HEMOBLASTOSES

The early stages of hemopoiesis repair as indicated by histologic exam inations of trephine biopsy specimens (visual assessment and morphomet ry) are characterized in 39 patients with hemoblastoses, 33 of these w ith acute leukemia, 4 with chronic myeloleukemia, and 2 with lymphobla stic lymphosarcoma, following transplantation of allogeneic (n = 19), syngeneic (n = 5), and autologous (n = 15) bone marrow after condition ing with cyclophosphamide plus total radiation exposure in 27 patients and myelosan with cyclophosphamide in 12 ones. Hemopoiesis repair was found to be slower after autologous transplantation of bone marrow th an after allogeneic transplantation and in patients following conditio ning with cyclophosphamide and total irradiation in comparison with th ose pretreated with myelosan and cyclophosphamide. Patients' age over 25, diagnosis of the disease more than 12 months before transplantatio n, and variant of leukemia (nonlymphoblastic) were the factors exertin g negative influence on the rate of hemopoiesis recovery.