Objective: The authors examined ambulatory ECG changes during panic at
tacks in patients with panic disorder. Method: Ten otherwise healthy w
omen with panic disorder and complaints of chest pain during panic att
acks underwent a symptom-limited exercise test on a treadmill and then
wore and ambulatory ECG monitor with software designed to detect and
record ischemic events and used a hand-held computer for up to 6 days.
Results: Eight of the women had panic attacks while using the han-hel
d computer and the ECG monitor. No ischemic events occurred during any
of the exercise tests. Twelve tachycardiac events occurred during pan
ic attacks and 84 tachycardiac events occurred that were not associate
d with panic attacks. Panic attacks were associated with significantly
more symptoms than were tachycardiac episodes. Conclusions: In this g
roup of otherwise healthy women with panic disorder and chest pain, am
bulatory ischemic changes were not recorded during panic attacks.