THE EFFECT OF DISODIUM EDETATE AND SODIUM-CHLORIDE ON THE STABILITY OF ETHYLMERCURY ARISING FROM THE DECOMPOSITION OF THIMEROSAL (THIOMERSAL)

Authors
FARIDAH,"MCDONALD C PARKIN JE
Citation
C. Faridah,"mcdonald et Je. Parkin, THE EFFECT OF DISODIUM EDETATE AND SODIUM-CHLORIDE ON THE STABILITY OF ETHYLMERCURY ARISING FROM THE DECOMPOSITION OF THIMEROSAL (THIOMERSAL), Drug development and industrial pharmacy, 21(20), 1995, pp. 2403-2410
Citations number
25
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drug development and industrial pharmacy → ACNP
ISSN journal
03639045
Volume
21
Issue
20
Year of publication
1995
Pages
2403 - 2410
Database
ISI
SICI code
0363-9045(1995)21:20<2403:TEODEA>2.0.ZU;2-2
Abstract
The effect of disodium edetate and sodium chloride on the stability of the ethylmercuric ion arising from the decomposition of thiomerosal h as been investigated using species-specific chromatographic assays. Di sodium edetate stabilises both the ethylmercuric ion and thimerosal wh ereas chloride stabilises the ethylmercuric ion but promotes decomposi tion of the thimerosal.