OSTEOGENESIS BY BONE-MARROW STROMAL CELLS MAINTAINED ON TYPE-I COLLAGEN MATRIX GELS IN-VIVO

In this study, we demonstrated that bone marrow stromal cells maintain ed on type I collagen matrix induced bone in vivo, The formed bone con tained bone marrow, and the process of bone formation occurred without cartilage formation, Bone marrow stromal cells differentiated into os teoblasts on type I collagen matrix in vitro, but types II, III, and V collagens did not possess this activity, These findings imply that ty pe I collagen matrix offers a suitable environment for the induction o f osteoblastic differentiation in vitro and osteogenesis in vivo. (C) 1997 by Elsevier Science Inc.