NEONATAL IGA AND IGE LEVELS AMONG INFANTS WITH PATERNAL HEREDITY FOR ATOPIC DISEASE

Citation
G. Lilja et al., NEONATAL IGA AND IGE LEVELS AMONG INFANTS WITH PATERNAL HEREDITY FOR ATOPIC DISEASE, Allergy, 50(9), 1995, pp. 723-728
Citations number
32
Categorie Soggetti
Allergy,Immunology
Journal title
ISSN journal
01054538
Volume
50
Issue
9
Year of publication
1995
Pages
723 - 728
Database
ISI
SICI code
0105-4538(1995)50:9<723:NIAILA>2.0.ZU;2-P
Abstract
Serum IgA and IgE levels were studied in the postnatal period in 21 in fants having a paternal heredity of atopic disease. Three different sa mpling techniques were used, aspirated cord blood (CB), gravity-collec ted cord blood, and capillary collected blood at 4-5 days of age. Sign ificant differences among the three sampling techniques were recorded for IgA (P < 0.01), but not for IgE. The IgA levels decreased from bir th to 4-5 days of age in 90% (19/21) of the infants (P < 0.01). The co rresponding decrease in IgE levels was 20%. This postnatal difference in the frequency of decreasing/increasing IgA and IgE levels was signi ficant (P < 0.05). An analysis of CB IgA to detect maternal contaminat ion of CB was found to be of questionable value, since only 50% (2/4) of the cases with an elevated CB-IgA level could be considered contami nated. The results of this study further emphasize that aspiration of CB and capillary collection of blood at 4-5 days of age are the best s ampling techniques to avoid contamination. The general finding that pa ternal heredity had no significant influence on infant IgE contrasts w ith the strong influence of maternal heredity. Further studies will sh ow whether the explanation lies in genetic or transplacental factors, or in both kinds of factors.