CROSS-SENSITIVITY AMONG OXICAMS IN PIROXICAM-CAUSED FIXED DRUG ERUPTION - 2 CASE-REPORTS

Fixed drug eruption (FDE) caused by oxicams is very rare. There are fe w reports of FDE induced by piroxicam, and this explains why cross-sen sitivity among oxicams (piroxicam, tenoxicam, and droxicam) has been s tudied in only one patient. The patch test on residual lesions has lat ely been used by some authors in FDE diagnosis with variable results. We describe two cases of piroxicam-caused FDE and demonstrate cross-se nsitivity among piroxicam, tenoxicam, and droxicam in both of them. On e patient had residual lesions and the patch test was useful for diagn osis and cross-sensitization studies. The second patient had no:residu al lesions, and the patch test was negative on normal but previously,a ffected skin; therefore, the study was performed by single-blind contr olled oral challenge.