CALCIFYING AMYLOIDOMA OF THE BREAST

In this case, a distinctive amyloid tumor of the breast clinically sim ulated carcinoma, although the patient related onset to trauma, Hepato splenomegaly, elevated globulins, and anemia led to identification of large amounts of monoclonal IgG-kappa production, The patient died of renal failure within several months despite chemotherapy, The matrix o f the breast tumor was tinctorially characteristic of amyloid light ch ain (AL) protein, The mass contained islands of plasma cells that morp hologically suggested local production of amyloid matrix, Moreover, pl asma cell and matrix immunohistochemically displayed reactivity of IgG -kappa protein, indicating a clonal plasma cell infiltrate, Pseudo-aci nar arrangement of plasma cells may be misinterpreted as: epithelial c ells in needle biopsy specimens, The notion that some amyloidomas may represent in situ production of protein by clonal immunocytes (''secre tory immunocytomas'') should be further studied.