THE SYNTHESIS OF PYRAZOLO[4,3-C]-ARYL[E]FUSED AND IMIDAZO[4,5-C]-ARYL[E]FUSED PYRIDINES AS STRUCTURAL ANALOGS OF 4-AMINONICOTINOATES

Authors
BENHAM CD BLACKBURN TP JOHNS A KOTECHA NR MARTIN RT THOMAS DR THOMPSON M WARD RW
Citation
Cd. Benham et al., THE SYNTHESIS OF PYRAZOLO[4,3-C]-ARYL[E]FUSED AND IMIDAZO[4,5-C]-ARYL[E]FUSED PYRIDINES AS STRUCTURAL ANALOGS OF 4-AMINONICOTINOATES, Bioorganic & medicinal chemistry letters, 5(21), 1995, pp. 2455-2460
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
21
Year of publication
1995
Pages
2455 - 2460
Database
ISI
SICI code
0960-894X(1995)5:21<2455:TSOPAI>2.0.ZU;2-L
Abstract
A series of 4-aminobenzothienopyridine-3-carboxylates 4 to 10 has been prepared and the SAR of these GABA(A) modulators discussed, Replaceme nt of the 4-aminonicotinoate moiety by imidazo [4,5-c] ring fusion pro vides potent bioisosteres 12 to 14.