METHANODIBENZOSUBERYLPIPERAZINES AS POTENT MULTIDRUG-RESISTANCE REVERSAL AGENTS

Authors
PFISTER JR MAKRA F MUEHLDORF AV WU H NELSON JT CHEUNG P BRUNO NA CASEY SM ZUTSHI N SLATE DL
Citation
Jr. Pfister et al., METHANODIBENZOSUBERYLPIPERAZINES AS POTENT MULTIDRUG-RESISTANCE REVERSAL AGENTS, Bioorganic & medicinal chemistry letters, 5(21), 1995, pp. 2473-2476
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
21
Year of publication
1995
Pages
2473 - 2476
Database
ISI
SICI code
0960-894X(1995)5:21<2473:MAPMR>2.0.ZU;2-#
Abstract
Annellation of a cyclopropyl group to the dibenzosuberane moiety of th e prototypical agent MS-073 afforded potent multiple drug resistance m odulators. The chiral differentiation observed for the enantiomers of some of these compounds points to a specific interaction with the drug efflux pump, glycoprotein p170, in contrast to the less specific memb rane interaction seen with less potent agents.