THE ENANTIOSELECTIVE SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF NOVELARYL-SPHINGOLIPID PKC INHIBITORS

Authors
MERRIMAN G TEGELER JJ HAMER RRL RAUCKMAN BS FREED BS KURTZ ES BAILEY SC ORTEGANANOS M PRZEKOP PA HELLYER L
Citation
G. Merriman et al., THE ENANTIOSELECTIVE SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF NOVELARYL-SPHINGOLIPID PKC INHIBITORS, Bioorganic & medicinal chemistry letters, 5(21), 1995, pp. 2483-2488
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
21
Year of publication
1995
Pages
2483 - 2488
Database
ISI
SICI code
0960-894X(1995)5:21<2483:TESAAA>2.0.ZU;2-A
Abstract
Recently we identified three promising topically active antiinflammato ry agents (2, 3, and 4) from a series of racemic aryl-sphingolipids th at inhibit protein kinase C (PKC). We now wish to report the enantiose lective synthesis of the aforementioned leads and their comparative bi ological profile. The individual enantiomers examined are equipotent t o their racemate in vitro and in vivo.