HIGH-AFFINITY FKBP-12 LIGANDS DERIVED FROM (R)-(-)-CARVONE - SYNTHESIS AND EVALUATION OF PK506 PYRANOSE RING REPLACEMENTS

Authors
TATLOCK JH KALISH VJ PARGE HE KNIGHTON DR SHOWALTER RE LEWIS CT FRENCH JV VILLAFRANCA JE
Citation
Jh. Tatlock et al., HIGH-AFFINITY FKBP-12 LIGANDS DERIVED FROM (R)-(-)-CARVONE - SYNTHESIS AND EVALUATION OF PK506 PYRANOSE RING REPLACEMENTS, Bioorganic & medicinal chemistry letters, 5(21), 1995, pp. 2489-2494
Citations number
32
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
21
Year of publication
1995
Pages
2489 - 2494
Database
ISI
SICI code
0960-894X(1995)5:21<2489:HFLDF(>2.0.ZU;2-2
Abstract
The preparation and evaluation of potent small molecule inhibitors of FKBP-12 rotamase activity is described. These ligands contain many of the structural features of the FK506 pyranose ring region, yet are syn thetically more accessible. The versatility of these FKBP-12 ligands i s demonstrated with respect to effector domain exploration.