SYNTHESIS OF NOVEL IODINATED RADIOLIGANDS WITH HIGH-AFFINITY AND SELECTIVITY FOR CCK-B GASTRIN RECEPTORS/

Authors
HORWELL DC HUNTER JC KNEEN CO PRITCHARD MC
Citation
Dc. Horwell et al., SYNTHESIS OF NOVEL IODINATED RADIOLIGANDS WITH HIGH-AFFINITY AND SELECTIVITY FOR CCK-B GASTRIN RECEPTORS/, Bioorganic & medicinal chemistry letters, 5(21), 1995, pp. 2501-2506
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
21
Year of publication
1995
Pages
2501 - 2506
Database
ISI
SICI code
0960-894X(1995)5:21<2501:SONIRW>2.0.ZU;2-F
Abstract
The syntheses of two non-peptide radio-iodinated ligands [I-125]-PD142 308 and [I-125]-PD142251 with high affinity and selectivity for the CC K-B/gastrin receptor are described via a route which introduces the ra diolabel at the final or penultimate step. The CCK-A and CCK-B binding affinities of both ligands are described.