KELATORPHAN AND RELATED ANALOGS - POTENT AND SELECTIVE INHIBITORS OF LEUKOTRIENE A(4) HYDROLASE

Authors
PENNING TD ASKONAS LJ DJURIC SW HAACK RA YU SS MICHENER ML KRIVI GG PYLA EY
Citation
Td. Penning et al., KELATORPHAN AND RELATED ANALOGS - POTENT AND SELECTIVE INHIBITORS OF LEUKOTRIENE A(4) HYDROLASE, Bioorganic & medicinal chemistry letters, 5(21), 1995, pp. 2517-2522
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
21
Year of publication
1995
Pages
2517 - 2522
Database
ISI
SICI code
0960-894X(1995)5:21<2517:KARA-P>2.0.ZU;2-E
Abstract
The hydroxamic acid-containing peptide kelatorphan, a known inhibitor of enkephalin-degrading enzymes, is a potent, non-competitive inhibito r of leukotriene A(4) (LTA(4)) hydrolase. Analogs of kelatorphan were prepared and several significantly and selectively inhibited both the hydrolase and aminopeptidase activity of the enzyme.