STEREOCHEMICAL PREFERENCES AND REQUIREMENT FOR THE 3-HYDROXYL GROUP IN NOVEL ANTICONVULSANT 4-FLUOROBENZOYLAMINO BENZOPYRANS

Authors
BROWN TH CAMPBELL CA CHAN WN EVANS JM MARTIN RT STEAN TO STEMP G STEVENS NC THOMPSON M UPTON N VONG AK
Citation
Th. Brown et al., STEREOCHEMICAL PREFERENCES AND REQUIREMENT FOR THE 3-HYDROXYL GROUP IN NOVEL ANTICONVULSANT 4-FLUOROBENZOYLAMINO BENZOPYRANS, Bioorganic & medicinal chemistry letters, 5(21), 1995, pp. 2563-2566
Citations number
5
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
21
Year of publication
1995
Pages
2563 - 2566
Database
ISI
SICI code
0960-894X(1995)5:21<2563:SPARFT>2.0.ZU;2-#
Abstract
A cis 3S,4S isomer, derived stereospecifically from an anticonvulsant trans 3R,4S-(para-fluorobenzoylamino)-benzopyran using the DAST reagen t, has been shown to possess anticonvulsant properties. In contrast th e cis 3R,4R enantiomer did not possess anticonvulsant properties but c aused blood pressure to fall.