GENERAL LINEAR COMPARTMENT MODEL WITH ZERO INPUT .3. FIRST PASSAGE RESIDENCE TIME OF ENZYME-SYSTEMS

In this paper, we present an alternative procedure to derive the resid ence times of enzyme and compartment systems. This procedure allows to express the residence time by a general, symbolic and simplified form ula relating it directly with the rate constants. It is applicable to any enzyme reaction scheme which can be formulated as a set of first-o rder or pseudo-first order interconversions, without any other restric tion. A computer program has been developed that greatly facilitates t he task of the residence time derivations. The above analysis was extr apolated to any linear compartment model.